Serial measurements of SIRS criteria to identify unique phenotypes of sepsis: A Microbiologic Approach

Introduction: The utility of serial scoring systems in identifying distinct sepsis phenotypes remains unknown. Methods: Eligible adults were classified into culture-positive (Cx+) and culture-negative (Cx-) groups alongside pre-defined culture subgroups. Average SIRS & SEP (novel system) scores calculated at t = 0 hours 3,6,12 24 before after 0. primary outcome was a difference SIRS/SEP amongst those that Cx+ or Cx- any time point. Secondary outcomes comparing total component microbiologic subgroups over points. Results: 4,701 3254 patients met eligibility criteria. Statistically significant differences seen the average score between Cx + six (Cx+ 1.40+1.04 vs 1.35+1.01) 12 0.95+0.95 0.90+0.90) hematologic, urologic, neurologic had numerous points T Similar findings observed with scores. (including subgroups) consistently doubled both an eventual return to baseline values but different gradients. Conclusion: Significant sequential This approach homogenous cohorts has potential identify efficiently practically. Consistent increases decreases may allow for early detection, intervention, provision real-time monitoring therapeutic responses concerns sepsis.